Genome-wide analysis of plant glutaredoxin systems

Genome-wide analysis of plant glutaredoxin systems.

The recent release of the first tree genome (Populus trichocarpa) has allowed a comparison to be made of the multigenic glutaredoxin (Grx) and glutathione reductase (GR) families of this tree with those of other sequenced organisms and especially of the two other fully sequenced plant species, Arabidopsis thaliana and Oryza sativa. Grxs are small proteins involved in disulphide bridge or protei...

Predicting CpG Islands and DNA Methlation in the Cow Genome Using DNA Microarray Meta-Analysis and Genome Wide Scanning

DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...

Systems-Level Analysis of Genome-Wide Association Data

Genome-wide association studies (GWAS) have emerged as the method of choice for identifying common variants affecting complex disease. In a GWAS, particular attention is placed, for obvious reasons, on single-nucleotide polymorphisms (SNPs) that exceed stringent genome-wide significance thresholds. However, it is expected that many SNPs with only nominal evidence of association (e.g., P < 0.05)...

Thioredoxin and glutaredoxin systems.

Genome-wide association analysis

Genome-wide association (GWA) studies have become overwhelmingly popular in the last few years as a means to elucidate associations between particular alleles in one’s DNA and a predisposition to disease, using genetic data from unrelated individuals randomly sampled from a population (Balding, 2006; WTCCC, 2007). The recent availability of large amounts of such population genetic data necessit...